A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines |
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Authors: | Elwell Kyler E Hall Casey Tharkar Shweta Giraud Yvonne Bennett Byron Bae Chulsung Carper Stephen W |
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Institution: | aChemistry Department, PO Box 454003, UNLV, Las Vegas, NV 89154-4003, USA |
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Abstract: | Novel cisplatin analogs dichloro4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]platinum (1) and fac-tricarbonylchloro4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]rhenium (3) were synthesized and evaluated for their cytotoxicity. While 3 was not cytotoxic, 1 was 14 to 125 times more lethal than cisplatin in breast, prostate, and lung cancer cell lines. Compound 1 was able to induce apoptosis and the presence of the platinum atom was essential to its function as a cytotoxin. |
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Keywords: | 2 2′-Bipyridine Rhenium Platinum MDA-MB-231 MDA-MB-435 A549 DU-145 |
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