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Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment |
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| Authors: | E. Moustacchi D. Papadopoulo C. Diatloff-Zito M. Buchwald |
| Affiliation: | (1) Institut Curie — Biologie, 26 rue d'Ulm, F-75231 Paris Cedex 05, France;(2) The Hospital for Sick Children, Toronto, Ontario, Canada;(3) the University of Toronto, Toronto, Ontario, Canada |
| Abstract: | Summary The two genetic complementation groups reported for Fanconi's anemia (FA) correspond to two phenotypic classes as characterized by measurements of the rate of DNA semiconservative synthesis after 8-methoxypsoralen photo-addition. This test allows a rapid genetic classification of FA patients which appears to be a prerequisite for investigations of the biochemical defect(s) in FA. |
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