Notch信号通路与生殖干细胞研究进展

Notch信号通路是一个在进化中高度保守的信号通道，具有调控细胞增殖、分化及凋亡的作用。近年来，随着研究的不断深入，发现Notch信号通路与生殖干细胞的增殖分化及干细胞微环境的作用机理密切关联，Notch信号通路在生殖系统发育及疾病治疗中的作用机制逐渐引起人们的广泛关注。该文综合论述了Notch信号通路的生理特性及功能，重点阐述Notch信号通路在精原干细胞、卵巢生殖干细胞及生殖干细胞微环境系统中的调控机制。

Research Progress on Notch Signaling Pathway and Germline Stem Cells

As a high evolutionarily conserved system during evolution, Notch signaling pathway participates in regulation of cellular differentiation, proliferation and death. In recent years, researches have shown that the element of Notch signaling pathway is complex, which is primarily related to proliferation and differentiation of germline stem cells and the role of stem cell niche. It also plays an extremely important role in reproductive system development and disease treatment. In this study, we summarized the physiological characteristics and functions of Notch signaling pathway, and focused on the role of regulating onfemale germline stem cells, male germline stem cells and germline stem cell niche.