| thoA介导的细胞骨架在肿瘤发生发展中的作用 |
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| 引用本文： | 王雪,王维莉,任雨,庄海慧,王萍.thoA介导的细胞骨架在肿瘤发生发展中的作用[J].细胞生物学杂志,2014(2):267-273. |
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| 作者姓名： | 王雪 王维莉 任雨 庄海慧 王萍 |
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| 作者单位： | [1]宁波大学医学院浙江省病理生理学技术研究重点实验室,宁波315211 [2]宁波市泌尿肾病医院,宁波315101 |
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| 基金项目： | 国家自然科学基金（批准号：81071653、81372209）和浙江省自然科学基金（批准号：LYl3H160038）资助的课题 |
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| 摘 要： | RhoA是Ras超家族中具有GTP酶活性的一种小G蛋白分子。RhoA在肿瘤组织的高表达与肿瘤的恶性程度密切相关。另外，RhoA的酶活性通过信号通路参与和调节微丝（microfilament，MF）和微管（microtubule，MT）细胞骨架的重排。新近研究表明，活性RhoA调控细胞骨架改变，进而诱导细胞癌变及肿瘤细胞增殖、入侵、转移、屏障功能和凋亡等多种生命活动。因此，研究RhoA介导的细胞骨架在肿瘤发生发展中的作用具有重要意义。该文结合作者的最新研究成果，对RhoA及其分子机制作一综述。
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| 关 键 词： | RhoA 细胞骨架 肿瘤发生 肿瘤发展 |
Effects of RhoA-regulated Cytoskeleton in the Tumorigenesis |
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| Wang Xue,Wang Weili,Ren Yu,Zhuang Haihui,Wang Ping.Effects of RhoA-regulated Cytoskeleton in the Tumorigenesis[J].Chinese Journal of Cell Biology,2014(2):267-273. |
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| Authors: | Wang Xue Wang Weili Ren Yu Zhuang Haihui Wang Ping |
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| Institution: | 1.Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China; 2Department of Urologic Surgery, Ningbo Urology and Nephrology Hospital, Ningbo 315000, China) |
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| Abstract: | RhoA is a small G-protein of Ras homolog gene family, which has the GTPase activity. Higher protein expression is tightly related with malignancy. Furthermore, RhoA activity controls the signal pathway and regulates cytoskeletal rearrangements. Recent reports showed that RhoA activity-induced cytoskeleton played a pivotal role in regulating cell behaviors. Accordance with our research, this review summarizes recent progress in studying the mechanisms of RhoA-mediated cytoskeleton in tumorigenesis. |
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| Keywords: | RhoA cytoskeleton tumorigenesis tumor development |
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