哺乳动物精原干细胞的研究进展 |
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引用本文: | 萨初拉,顾婷玉,何志颖,Muren Herrid,王欣,乌云毕力格. 哺乳动物精原干细胞的研究进展[J]. 细胞生物学杂志, 2014, 0(3): 392-399 |
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作者姓名: | 萨初拉 顾婷玉 何志颖 Muren Herrid 王欣 乌云毕力格 |
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作者单位: | [1]内蒙古大学哺乳动物生殖生物学及生物技术教育部重点实验室,呼和浩特010021 [2]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海200031 [3]第二军医大学细胞生物学教研室,上海200433 [4]CSIRO Livestock Industries, FD McMaster Laboratory, Armidale, NSW 2350, Australia |
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基金项目: | 国家自然科学基金(批准号:31060168、31271469、31271474、31271042)资助的课题 |
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摘 要: | 精原干细胞是雄性体内可以永久维持的成体干细胞,它具有自我更新和分化的能力,保证了雄性个体生命过程中精子发生的持续进行,从而实现将遗传信息传递给下一代。精原千细胞不仅可在体外实现长期培养或诱导分化为各级生精细胞,并且可在特定条件下将其诱导去分化成为多能性干细胞。同样,这种多能性干细胞如同胚胎干细胞,可被诱导形成造血细胞、神经元细胞、肌细胞等多种类型细胞。鉴于其独具的生物学特性,精原干细胞在揭示精子的发生机制、治疗雄性不育和转基因动物等研究中具有重要价值。该文对精原干细胞在生物学特性、纯化培养、移植、体外诱导分化及其相关调控方面的各项研究进行了小结,综述了近年来的研究历程和最新研究成果。
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关 键 词: | 精原干细胞 诱导分化 移植 调控 |
Advances in the Research of Mammalian Spermatogonial Stem Cells |
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Affiliation: | Sachula Wu, Gu Tingyu, He Zhiying, Muren Herrid, Wang Xin, Uyunbilig Borjigin (1 The Key Laboratory of Mammalian Reproductive Biology and Biotechnology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China; 2The laboratory of Cellular and Molecular Biology, Shanghai Institute of Cell Biology and Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China; 3Department of Cell Biology, Second Military Medical University, Shanghai 200433, China; 4CSIRO Livestock Industries, FD McMaster Laboratory, Armidale, NSW 2350, Australia) |
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Abstract: | Spermatogonial stem cells (SSCs) are the adult stem cells that are capable of self-renewal and differentiation into sperm cells in the male body. SSCs can maintain capacity of spermatogenesis throughout life in males, thus transmit genetic information to next generation though sperm cells. Under in vitro culture conditions, SSCs could be induced into several cell types including hematopoietic cells, neurons and muscle cells besides various cells relative to spermatogenesis. As the cell model, SSCs become an important tool for the researches on spermatogenesis mechanism, regeneration of spermatogenesis in sterile individuals and reproduction of transgenic animals. This article reviewed recent advances in the studies including biological properties, purification, culture, transplantation, induced differentiations and molecular regulation underlining these differentiations of SSCs. |
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Keywords: | spermatogonial stem cell induced differentiation transplantation regulation |
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