| 基于痘苗病毒载体的恶性肿瘤基因治疗研究进展 |
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| 引用本文： | 王世兵,陈侃,孔祥东. 基于痘苗病毒载体的恶性肿瘤基因治疗研究进展[J]. 细胞生物学杂志, 2014, 0(1): 135-142 |
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| 作者姓名： | 王世兵 陈侃 孔祥东 |
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| 作者单位： | [1]浙江理工大学生命科学学院,科研实验中心,杭州310018 [2]浙江理工大学生命科学学院,生物材料与海洋生物资源研究所,杭州310018 |
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| 基金项目： | 国家自然科学基金（批准号：51272236,51002139）和浙江省自然科学基金（批准号：LY13H080005）资助的课题 |
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| 摘 要： | 基因治疗一直是肿瘤生物治疗的重要策略，而以溶瘤痘苗病毒为载体的肿瘤治疗近年来受到较多关注。该文总结了目前用于恶性肿瘤治疗的痘苗病毒和基于痘苗病毒载体的基因治疗研究进展及其在各个领域的成果。
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| 关 键 词： | 痘苗病毒 恶性肿瘤 基因治疗 病毒治疗 |
Oncolytic Vaccinia Virus Vector for Genetherapy of Cancer |
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| Wang Shibing,Chen Kan,Kong Xiangdong. Oncolytic Vaccinia Virus Vector for Genetherapy of Cancer[J]. Chinese Journal of Cell Biology, 2014, 0(1): 135-142 |
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| Authors: | Wang Shibing Chen Kan Kong Xiangdong |
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| Affiliation: | 1Research Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China; 2Bio-X Center, College of Life Sciences, Zhejiang Sci-Teeh University, Hangzhou 310018, China) |
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| Abstract: | Gene therapy has always been an important strategy for the biological treatment of tumor. Vaccinia virus has emerged as an attractive agent especially when used as an oncolytic virus vector. This review describes the use of vaccinia virus in cancer therapy as a oncolytic virus and the progress of vaccinia virus vector- based gene therapy and its achievements in various fields. |
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| Keywords: | vaccinia virus cancer gene therapy viral therapy |
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