Tom1L1在细胞信号转导及受体内吞中的研究进展

Tom1L1（Tom1 like 1）参与并调节细胞信号转导及受体运输通路。在不同细胞中Tom1L1对信号转导具有不同的调节作用。Tom1L1-CHC（clathrinheavychain）复合物减少Src蛋白在小窝（caveolae）处富集，从而阻碍Src蛋白与血小板衍生因子（platelet derived growth factor,PDGF）受体的结合。抑制PDGF受体介导的有丝分裂和转化信号传导。活化的表皮生长因子受体（epidermal growth factor receptor,EGFR）通过Src家族蛋白激酶（src family kinase，SFK）磷酸化T0m1L1，磷酸化的Tom1L1通过Grb2和Shc的桥梁作用与EGFR结合，介导EGFR的内吞进程。Tom1L1和Hrs（hepatocyte growth factor regulated tyrosine kinase substrate）、TSG101（tumor susceptibility gene 101）的相互作用表明，它也可能参与了泛素化蛋白分选入多泡体的过程。该文就其在细胞信号转导通路及受体内吞／分选过程的作用作一综述。

Progresses and Perspectives on the Role of Tom1L1 in Signal Transduction and Endocytosis Pathways

Tom1L1 （Toml like 1） participates in cell signal transduction pathways and receptors＇ endocytosis. It has different effects on cell signal transduction depending on cell types. Moreover, Tom1L1- CHC （clathrin heavy chain） complex represses mitogenic and transforming signals by reducing the level of Src in caveolae. EGFR （epidermal growth factor receptor） stimulates transient tyrosine phosphorylation of Tom1L1 by the SFK （src family kinases）, and pTom1L1 （phosphorylated Tom1L1） promotes endocytosis of EGFR bridged by Grb2 and She. Tom1L1 also interacts with Hrs （hepatocyte growth factor regulated tyrosine kinase substrate） and TSG 101 （tumor susceptibility gene 101）, which suggests that it might play a role in sorting of ubiquitinated proteins into MVB （multivesicular body）. This review will focus on the specific role of Tom1L1 in signal transduction pathways and the endocytosis/sorting of receptors.