| 干细胞治疗糖尿病足的实验研究进展 |
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| 引用本文： | 郭勇英,高怀林.干细胞治疗糖尿病足的实验研究进展[J].细胞生物学杂志,2014(4):530-539. |
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| 作者姓名： | 郭勇英 高怀林 |
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| 作者单位： | [1]河北医科大学研究生学院,石家庄050017 [2]河北以岭医药研究院,国家中医药管理局重点研究室（心脑血管络病）,石家庄050035 [3]河北医科大学附属以岭医院,河北省中医药络病理论指导糖尿病足防治重点研究室,石家庄050091 [4]河北省络病重点实验室,石家庄050035 |
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| 基金项目： | 国家高技术研究发展计划（863计划）（批准号：2011AA020115）、国家重点基础研究发展计划（973计划）（批准号：2012CB518606）和河北省中医药管理局课题f批准号：2012112）资助的课题 |
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| 摘 要： | 糖尿病足是指因糖尿病血管病变和（或）神经病变及感染等综合因素，导致I陵性进行性波及肢体大、中、微血管，引起足部疼痛、皮肤深溃疡或肢体坏疽的一种病变，是糖尿病的严重并发症之一。临床治疗非常棘手，难以取得令人满意的疗效，最终导致截肢甚至危及病患生命。因此，临床上迫切需要找到创伤小、易接受、疗效好的新的治疗方法。干细胞具有高度增殖和分化成为体内各种细胞的潜能，其可塑性强，为糖尿病足的治疗带来新前景，目前是国内外学者研究的热点之一。该文就干细胞移植治疗糖尿病足的实验研究进展作一综述。
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| 关 键 词： | 糖尿病足 干细胞移植 实验研究 |
The Progress of Experimental Study on Stem Cell Therapy for Diabetic Foot |
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| Guo Yongying,Gao Huailin.The Progress of Experimental Study on Stem Cell Therapy for Diabetic Foot[J].Chinese Journal of Cell Biology,2014(4):530-539. |
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| Authors: | Guo Yongying Gao Huailin |
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| Institution: | . (1Graduate School of Hebei Medical University, Shijiazhuang 050017, China; 2)qling Medical Research Institute of Hebei Province, Key Laboratory of State Administration of Traditional Chinese Medicine (cardio-cerebral vascular network disease), Shijiazhuang 050035, China; 3yiling Hospital of Hebei Medical University, Department of Guidance in Prevention and Treatment of Diabetic Foot on Hebei Province Chinese Medicine Theory of Collateral Disease, Shijiazhuang 050091, China; 4Key Laboratory of Network Disease of Hebei Province, Sh(jiazhuang 050035, China) |
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| Abstract: | The diabetic foot （DF） is caused by diabetic vascular disease and/or neuropathy and infections as well as other factors, resulting in chronic progressive affected limb, micro vessel, and causing foot pain, skin ulcers or gangrene of limbs in deep. It is one of the serious complications of diabetes, occasionally causing amputa- tion and even death. It is hard to obtain satisfactory effect, and clinical treatment is very difficult. Therefore, there is an urgent need to find a new treatment with fewer traumas, easier delivery, and good curative effect. Stem cells are capable of proliferation and differentiation into various kinds of cells. Their stronger plasticity brings new prospect for the treatment of diabetic foot. Currently, the stem cells attract attention of researchers worldwide. Here we re- view the progress on stem cell transplant therapy for the treatment of diabetic foot. |
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| Keywords: | diabetes foot stem cell transplantation experimental study |
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