Copper(II)/H(2)O(2)-mediated DNA cleavage: involvement of a copper(III) species in H-atom abstraction of deoxyribose units. |
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| Authors: | Amina Amine Zidane Atmani Abdelila El Hallaoui Michel Giorgi Marcel Pierrot Marius Réglier |
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| Institution: | Université Moulay Ismail, Faculté des Sciences de Meknès, Meknès, Morocco. |
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| Abstract: | A new bis-amido-copper(II) complex 2 has been prepared. In the presence of reducing agents (ascorbate or DTT) under air atmosphere or hydrogen peroxide, complex 2 exhibited interesting nuclease activities in the 1-10 microM concentration range. For explaining the activity observed with hydrogen peroxide, we propose the occurrence of a bis-amido-copper(III) intermediate and an oxidation mechanism involving a H-atom abstraction of deoxyribose moieties of DNA. |
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