| How does Mycobacterium leprae target the peripheral nervous system? |
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| 作者姓名： | Rambukkana A |
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| 摘 要： |
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How does Mycobacterium leprae target the peripheral nervous system? |
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| Rambukkana A.How does Mycobacterium leprae target the peripheral nervous system?[J].Trends in Microbiology,2000,8(1):23-28. |
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| Authors: | Rambukkana A |
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| Institution: | Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. rambuka@rockvax.rockefeller.edu |
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| Abstract: | Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules. |
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