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Prognostic significance of NDRG1 expression in oral and oropharyngeal squamous cell carcinoma |
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| Authors: | Marcelo dos Santos Ana Maria da Cunha Mercante Fábio Daumas Nunes Andréia Machado Leopoldino Marcos Brasilino de Carvalho Diana Gazito Rossana Verónica Mendoza López Paula Blandina Olga Chiappini Paulo Bentes de Carvalho Neto Erica Erina Fukuyama Eloiza Helena Tajara Iúri Drumond Louro Adriana Madeira álvares da Silva |
| Institution: | 1. Universidade Federal do Espírito Santo, Avenida Marechal Campos, 1468, Maruípe, Vitória, ES, CEP 29043-900, Brazil 2. Laboratório de Biologia Molecular do Hospital Heliópolis, Rua C?nego Xavier, 276, Sacom?, S?o Paulo, SP, CEP 04231-030, Brazil 3. Anatomia Patológica do Hospital Heliópolis, Rua C?nego Xavier, 276, Sacom?, S?o Paulo, SP, CEP 04231-030, Brazil 4. Departamento de Estomatologia, Faculdade de Odontologia da Universidade de S?o Paulo, Avenida Prof. Lineu Prestes, 2227, Cidade Universitária, S?o Paulo, SP, CEP 05508-000, Brazil 5. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas da Universidade de S?o Paulo, Avenida do Café, s/n, Campus Universitário, Ribeir?o Preto, SP, CEP 14040-903, Brazil 7. Departamento de Epidemiologia, Faculdade de Saúde Pública da Universidade de S?o Paulo, Avenida Doutor Arnaldo, 715, S?o Paulo, SP, CEP 01255-000, Brazil 8. Instituto do Cancer Arnaldo Vieira de Carvalho, Rua Doutor Cesário Motta Júnior, 112, Vila Buarque, S?o Paulo, SP, CEP 01221-020, Brazil 10. Departamento de Biologia Molecular, Faculdade de Medicina, Avenida Brigadeiro Faria Lima, 5416, Vila S?o Pedro, S?o José do Rio Preto, SP, CEP 15090-000, Brazil 11. Departamento de Genética e Biologia Evolutiva, Instituto de Biociências da Universidade de S?o Paulo, Rua do Mat?o, 321, Cidade Universitária, S?o Paulo, SP, CEP 05508-090, Brazil 6. Departamento de Ciências Biológicas, Núcleo de Genética Humana e Molecular, Universidade Federal do Espírito Santo, Avenida Marechal Campos, 1468, Maruípe, Vitória, ES, CEP 29043-900, Brazil 12. Departamento de Produ??o Vegetal/Biologia, Universidade Federal do Espírito Santo-DPV/Biologia, Alto Universitário s/n, Alto Universitário, Caixa Postal 16, Alegre, ES, CEP 29500-000, Brazil |
| Abstract: | Human N-myc downstream-regulated gene 1 (NDRG1) is a metastasis suppressor gene with several potential functions, including cell differentiation, cell cycle regulation and response to hormones, nickel and stress. The purpose of this study was to investigate the immunoexpression of NDRG1 in oral and oropharyngeal squamous cell carcinomas searching for its role in the clinical course of these tumors. We investigated immunohistochemical expression of NDRG1 protein in 412 tissue microarray cores of tumor samples from 103 patients with oral and oropharyngeal squamous cell carcinomas and in 110 paraffin-embedded surgical margin sections. The results showed NDRG1 up-regulation in 101/103 (98.1?%) tumor samples, but no expression in any normal tissue sample. Western blot assays confirmed the immunohistochemical findings, suggesting that lower levels of NDRG1 are associated with a high mortality rate. NDRG1 overexpression was related to long-term specific survival (HR?=?0.38; p?=?0.009), whereas the presence of lymph-node metastasis showed the opposite association with survival (HR?=?2.45; p?=?0.013). Our findings reinforce the idea that NDRG1 plays a metastasis suppressor role in oral and oropharyngeal squamous cell carcinomas and may be a useful marker for these tumors. |
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