Altered gene expression of NIDD in dorsal root ganglia and spinal cord of rats with neuropathic or inflammatory pain |
| |
Authors: | Meng-Ling Chen Chun Cheng Qing-Shan Lv Zhi-Qin Guo Ying Gao Shang-Feng Gao Xin Li Shu-Qiong Niu Shu-Xian Shi Ai-Guo Shen |
| |
Institution: | (1) The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, P.R. China;(2) Institute of Neurobiology, Fudan University, Shanghai, 200032, China |
| |
Abstract: | Nitric oxide and nitric oxide synthases are key players in synaptic plasticity events in spinal cord (SC), which underlies
the chronic pain states. To date, little is known about the molecular mechanisms regulating the activity of nitric oxide synthases
in nociceptive systems. The present study was aimed at the determination of the gene expression of nNOS-interacting DHHC domain-containing
protein with dendritic mRNA (NIDD), a recently identified protein regulating nNOS enzyme activity, in rat SC and dorsal root
ganglia (DRG) and studying its regulation in states of nociceptive hypersensitivity in a rat model of neuropathic or inflammatory
pain. It was found that NIDD mRNA was predominantly expressed in nociceptive primary neurons and in neurons of the spinal
dorsal horn (DH) and the number of NIDD-positive neurons in the corresponding DRG or SC increased significantly following
induction of chronic hyperalgesia. Meanwhile, remarkable changes of nNOS were detected under such pain conditions. Our data
suggest a potential role for NIDD in the maintenance of thermal pain hypersensitivity possibly via regulating the nNOS activity.
Meng-Ling Chen and Chun Cheng are contributed equally to this work. |
| |
Keywords: | Neuronal nitric oxide synthase nNOS-interacting DHHC domain-containing protein with dendritic mRNA Pain Complete Freund’ s adjuvant Nerve injury |
本文献已被 PubMed SpringerLink 等数据库收录! |
|