A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants |
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| Authors: | Yunqi Li C Russell Middaugh Jianwen Fang |
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| Affiliation: | (1) Applied Bioinformatics Laboratory, the University of Kansas, Lawrence, KS 66047, USA;(2) Department of Pharmaceutical Chemistry, the University of Kansas, Lawrence, KS 66047, USA |
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| Abstract: | Background The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical problem is the lack of reliable methods to estimate the relative thermostability of possible mutants. |
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