Interaction of the heterotrimeric G protein alpha subunit SSG-1 of <Emphasis Type="Italic">Sporothrix schenckii</Emphasis> with proteins related to stress response and fungal pathogenicity using a yeast two-hybrid assay |
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Authors: | Lizaida Pérez-Sánchez Elizabeth González Emilee E Colón-Lorenzo Waleska González-Velázquez Ricardo González-Méndez Nuri Rodríguez-del Valle |
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Institution: | 1.Department of Microbiology and Medical Zoology, Medical Sciences Campus,University of Puerto Rico,San Juan,USA;2.Department of Radiological Sciences, Medical Sciences Campus,University of Puerto Rico,San Juan,USA |
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Abstract: | Background Important biological processes require selective and orderly protein-protein interactions at every level of the signalling
cascades. G proteins are a family of heterotrimeric GTPases that effect eukaryotic signal transduction through the coupling
of cell surface receptors to cytoplasmic effector proteins. They have been associated with growth and pathogenicity in many
fungi through gene knock-out studies. In Sporothrix schenckii, a pathogenic, dimorphic fungus, we previously identified a pertussis sensitive G alpha subunit, SSG-1. In this work we inquire
into its interactions with other proteins. |
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