Haplotype allelic classes for detecting ongoing positive selection |
| |
| Authors: | Julie Hussin Philippe Nadeau Jean-François Lefebvre Damian Labuda |
| |
| Institution: | 1.Bioinformatics Program, Department of Biochemistry,Université de Montréal,Montréal,Canada;2.Research Center,H?pital Sainte-Justine,Montréal,Canada;3.Department of Pediatrics,Université de Montréal,Montréal,Canada |
| |
| Abstract: | Background Natural selection eliminates detrimental and favors advantageous phenotypes. This process leaves characteristic signatures
in underlying genomic segments that can be recognized through deviations in allelic or haplotypic frequency spectra. To provide
an identifiable signature of recent positive selection that can be detected by comparison with the background distribution,
we introduced a new way of looking at genomic polymorphisms: haplotype allelic classes. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
