Comparative effect of amidated pectin and psyllium on cholesterol homeostasis in rats |
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Authors: | Milan Marounek Zdeněk Volek Eva Sk?ivanová Jan T?ma Dagmar Du?ková |
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Institution: | (1) Department of Polymer Science, Bundelkhand University, Jhansi, 281384, India;(2) Materials Science Centre, I.I.T. Kharagpur, 721302, India; |
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Abstract: | The effects of amidated pectin and psyllium on serum, hepatic and faecal cholesterol concentration were compared in female
rats fed diets supplemented with palm fat and cholesterol at 50 and 10 g/kg, respectively. Control rats were fed a diet supplemented
with cellulose at 60 g/kg. In treated rats, cellulose was replaced with either amidated pectin or psyllium. Amidated pectin
and psyllium intake significantly decreased serum cholesterol from 3.41 μmol/ml (control) to 1.68 and 2.04 μmol/ml, respectively,
and hepatic cholesterol from 31.9 μmol/g (control) to 7.2 and 9.0 μmol/g, respectively. Histology with lipid-staining Sudan
Black B revealed that liver tissue from control rats was infiltrated with lipids, but staining was absent in livers of treated
rats. No hepatic pathophysiology was apparent in treated rats. Amidated pectin and psyllium intake significantly increased
faecal fat content. Faecal cholesterol content was significantly increased in rats that were fed amidated pectin, and non-significantly
increased in rats that were fed psyllium. Body weight and food intake did not differ among treatment groups. In conclusion,
amidated pectin, a novel sequestrant of sterols, demonstrated a similar effect on rat serum and hepatic cholesterol concentration
to psyllium, which is a well-established hypocholesterolaemic agent. |
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