Metabolic products of microorganisms |
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| Authors: | Hartwig Müller Rolf Furter Hans Zähner Dora M. Rast |
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| Affiliation: | (1) Lehrstuhl Mikrobiologie I, Institut für Biologie II der Universität Tübingen, Auf der Morgenstelle 28, D-7400 Tübingen, Federal Republic of Germany;(2) Institut für Pflanzenbiologie, Universität Zürich, Zollikerstrasse 107, CH-8008 Zürich, Switzerland |
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| Abstract: | The effect of the nucleoside-peptide antibiotics nikkomycin Z, nikkomycin X, and polyoxin A was tested on chitosomal chitin synthetase from yeast cells of the dimorphic fungus Mucor rouxii. The Ki was 0.6  M for polyoxin A and 0.5 M for nikkomycin X; nikkomycin Z was slightly less inhibitory (Ki=3.5M). Whereas the minimum inhibitory concentrations of the nikkomycins for growth and germination were quite low (about 1M, or lower), polyoxin A displayed no antifungal activity against yeast cells and sporangiospores of the test organism, even when present in high concentrations. These results are discussed with respect to structure/activity relationships.Abbreviations MIC minimum inhibitory concentration (i.e. concentration required to completely suppress growth: cf. Drews, 1979) - GlcNAc N-acetyl-d-glucosamine - UDP-GlcNAc uridine 5 -diphospho-N-acetyl-d-glucosamineMetabolic products of microorganisms. 202. H. P. Kaiser and W. Keller-Schierlein: Strukturaufklärung von Elaiophylin: Spektroskopische Untersuchungen und Abbau. Helv. Chim. Acta 64: 407–424 (1981) |
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| Keywords: | Fungal chitin synthetase Inhibitors of chitin synthetase Nikkomycin Z Nikkomycin X Polyoxin A Ki values MIC values Mucor rouxii |
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