A third common allele in the transferrin system,Tf
C3
, detected by isoelectric focusing |
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Authors: | P Kühnl W Spielmann |
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Institution: | (1) Department of Genetics, The Hebrew University, Jerusalem, Israel;(2) Abteilung für Pathologie der Medizinischen Hochschule Lübeck, D-2400 Lübeck, Germany |
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Abstract: | Summary The fluorochrome Hoechst 33258 which binds preferentially to A-T base pairs, drastically inhibits the condensation of A-T-rich centromeric heterochromatin regions in mouse cell lines. The condensation of all other regions of these chromosomes is also inhibited to some extent. The human Y chromosome contains a large heterochromatic region, which is also rich in A-T base pairs. This chromosome is not affected by Hoechst 33258 in human leukocyte cell cultures. On the other hand, condensation of the multiple copies of human Y chromosome in the mouse-human cell hybrid RH-28Y-23 is inhibited and the chromosomes appear distorted in Hoechst 33258-treated cells. |
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