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A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation |
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| Authors: | Reza Mobini Bengt A Andersson Jonas Erjefält Mirjana Hahn-Zoric Michael A Langston Andy D Perkins Lars Olaf Cardell Mikael Benson |
| Affiliation: | (1) Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden;(2) Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden;(3) Department of Experimental Medicine, Lund University, Lund, Sweden;(4) Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA;(5) Department of Oto-rhino-largyngeology, Karolinska Institute, Stockholm, Sweden |
| Abstract: | BackgroundThe identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes. |
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