Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames) |
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| Authors: | Rafael M Cou?ago Milya Davlieva Ulrich Strych Ryan E Hill Kurt L Krause |
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| Affiliation: | (1) Department of Biochemistry, University of Otago, Dunedin, New Zealand;(2) Department of Biochemistry Rice University, Houston, TX, USA;(3) Department of Biology and Biochemistry, University of Houston, Houston, TX, USA |
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| Abstract: | Background Bacillus anthracis is the causative agent of anthrax and a potential bioterrorism threat. Here we report the biochemical and structural characterization of B. anthracis (Ames) alanine racemase (Alr Bax ), an essential enzyme in prokaryotes and a target for antimicrobial drug development. We also compare the native Alr Bax structure to a recently reported structure of the same enzyme obtained through reductive lysine methylation. |
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