Effects of haloperidol, clotrimazole, and pyridoxal-5′-phosphate on synaptic transmission in smooth muscles of the human colon |
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Authors: | A V Romanenko M M Grusha |
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Institution: | (1) Ministry of Public Health of Ukraine, Bogomolets National Medical University, Kyiv, Ukraine |
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Abstract: | In strips of smooth muscles of the human colon, haloperidol (Hal) and clotrimazole (Clo), in contrast to pyridoxal-5′-phosphate
(PP), suppressed spontaneous electrical and contractile activities of these strips and also post-inhibitory excitation developing
after inhibitory synaptic potentials (ISPs). Haloperidol, Clo, PP, and PP applied against the background of the action of
Nω-nitro-L-arginine noticeably changed the parameters of ISPs. The pattern of effect of Hal on synaptic inhibition in smooth
muscles was preserved against the background of the action of PP, and that of PP was preserved against the background of the
action of Hal.
Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 408–411, July–October, 2007. |
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Keywords: | intestinal smooth muscles haloperidol clotrimazole pyridoxal-5′ -phosphate |
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