Regulation of protein kinases; controlling activity through activation segment conformation |
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| Authors: | Nolen Brad Taylor Susan Ghosh Gourisankar |
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| Affiliation: | Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92116, USA. |
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| Abstract: | There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity. |
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