Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor |
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| Authors: | Marco Scianna Roeland M.H. Merks Luigi Preziosi Enzo Medico |
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| Affiliation: | aDepartment of Mathematics, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy;bNCSB-NISB, Science Park 904, 1098 XG Amsterdam, The Netherlands;cCWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands;dDepartment of Oncological Sciences and Laboratory of Oncogenomics, Institute for Cancer Research, University of Torino Medical School, Strada Provinciale 142, 10060 Candiolo, Italy |
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| Abstract: | The different behaviors of colonies of two cell lines, ARO (thyroid carcinoma-derived cells) and MLP-29 (mouse liver progenitor cells), in response to hepatocyte growth factor (HGF) are described deducing suitable cellular Potts models (CPM). It is shown how increased motility and decreased adhesiveness are responsible for cell–cell dissociation and tissue invasion in the ARO cells. On the other hand, it is shown that, in addition to the biological mechanisms above, it is necessary to include directional persistence in cell motility and HGF diffusion to describe the scattering and the branching processes characteristic of MLP-29 cells. |
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| Keywords: | Cellular Potts model Hepatocyte growth factor ARO cell line Cell– cell dissociation Invasive growth MLP-29 cell line Scattering |
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