Encapsulation of interleukin-2 in murine erythrocytes and subsequent deposition in mice receiving a subcutaneous injection |
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| Authors: | J R DeLoach K Andrews C L Sheffield |
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| Institution: | Veterinary Toxicology and Entomology Research Laboratory, U.S. Department of Agriculture, P.O., College Station, Texas 77841. |
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| Abstract: | Radiolabeled recombinant human interleukin-2 (IL-2) was successfully encapsulated in both mouse and sheep erythrocytes. Of the added IL-2, 70% was recovered bound to or encapsulated within the carrier cells. Erythrocytes containing IL-2 were stable in vitro and most of the IL-2 remained associated with the cells following a 16-h incubation at 37 degrees C. When carrier erythrocytes containing IL-2 were injected subcutaneously into mice, intact 35S]IL-2 was detectable in a number of tissues 3 days after injection. |
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