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Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus
Authors:G E Bunce  M Vessal
Affiliation:1. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China;2. Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning 530021, China;3. Department of Molecular Pharmacology at Albert Einstein College of Medicine, Bronx, New York 10461, USA;1. Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA;2. Department of Health and Exercise Science, Colorado State University, Ft. Collins, CO, USA;3. Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA;4. Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA;5. Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA;6. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA;1. Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;2. Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;3. Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran;4. Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran;5. Departments of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran;1. Jiangsu Livestock Embryo Engineering Laboratory, Nanjing Agricultural University, Nanjing, 210095, China;2. Portal Agri-Industries Co., Ltd., Xingdian Street, Pikou District, Nanjing, 210095, China;1. Department of Medicine F - Recanati, Rabin Medical Center -Beilinson Hospital, Petach Tikva, Israel;2. Statistical Counselling Unit, Rabin Medical Center – Beilinson Hospital, Petach Tikva, Israel;3. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
Abstract:A deficiency of vitamin B6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen.
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