Triiodothyronine (T3) neogenesis in lean and obese LA/N-cp rats |
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| Authors: | O L Tulp S T McKee |
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| Affiliation: | 1. Department of Cardiology, Isala Hospital, Zwolle, the Netherlands;2. Department of Cardiology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain;3. Department of Cardiology, IIS-Fundacion Jimenez Díaz Hospital, Madrid, Spain;4. Department of Cardiology, Hospital Universitario Quirón, Universidad Europea de Madrid & Hospital Ruber-Quirónsalud, Madrid, Spain;5. Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands;6. Department of Cardiology, Servicio de Urgencia Medica de Madrid (SUMMA 112), Madrid, Spain;7. Department of Cardiology, University Medical Center Groningen, Groningen, the Netherlands;8. Department of Cardiology, Codigo Infarto, Madrid, Spain;9. Department of Cardiology, Hospital 12 de Octubre, Madrid, Spain;10. Department of Cardiology, Hospital Clínico San Carlos, Madrid, Spain;11. Department of Cardiology, Hospital Gregorio Marañón, Madrid, Spain;12. Department of Cardiology, Hospital Puerta de Hierro, Madrid, Spain;13. Department of Cardiology, Hospital Fundación Alcorcón, Madrid, Spain;14. Department of Cardiology, Hospital Ramón y Cajal, Madrid, Spain;15. Department of Cardiology, Hospital de La Princesa, Madrid, Spain;p. Department of Cardiology, Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain;q. Department of Cardiology, Hospital de Getafe, Madrid, Spain;r. Diagram, Diagnostic Research and Management, Zwolle, the Netherlands;s. Department of Cardiology, Meander Medisch Centrum, Amersfoort, the Netherlands;t. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands;u. Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands;v. The Zena and Michael A Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York;1. Cardiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden;2. Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden;3. Department of Graduate School of Medicine (Cardiology), International University of Health and Welfare, Okawa, Japan;4. Minneapolis VA Center for Care Delivery and Outcomes Research, University of Minnesota, Minneapolis, Minnesota, USA;5. CVRM Evidence, BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden;6. CVRM Evidence, BioPharmaceuticals Medical, AstraZeneca, Oslo, Norway;7. Statisticon, Uppsala, Sweden;8. Winters Center for Heart Failure, Cardiovascular Research Institute, Baylor College of Medicine, Michael E. DeBakey VA Medical Center, Houston, Texas, USA;1. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota;2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota;1. Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia;2. Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia;3. Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China;4. Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, Australia;1. Duke Clinical Research Institute, Durham, North Carolina, USA;2. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA;3. Department of Cardiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada;4. Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA;5. Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA;6. Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA;7. Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA;8. Section of Cardiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada;1. Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA |
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| Abstract: | Pre-obese LA/N-cp rats consumed more food and gained weight more rapidly than their lean littermates, and measures of adipose tissue depots indicated that the excess weight was deposited principally as carcass fat. Serum T3 concentrations and resting metabolic rates were lower in corpulent than in lean animals, consistent with a greater efficiency of weight gain in those animals. In vitro measures of T3 neogenesis from T4 were lower in corpulent than in lean animals in liver, kidney, and skeletal muscle and greater in interscapular brown adipose tissue. The intracellular generation of T3 from T4 is a fundamental component of the normal adaptive response to alterations in diet and environment, and is an essential prerequisite for the expression of non-shivering thermogenesis. These results are consistent with a functional impairment in the activity of the enzyme T4-5'-deiodinase in peripheral tissues, and suggest that this impairment is contributory if not causative of obesity in this strain of rat. |
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