Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma |
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Authors: | GuiLan Wang JiRong Lu |
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Institution: | (1) Center for Clinical and Translational Science, Creighton University School of Medicine, CRISS II, Room 510, 2500 California Plaza, Omaha, NE 68178, USA |
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Abstract: | This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway
inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice
inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated
the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option
for treating and controlling chronic airway inflammation and asthma symptoms. |
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Keywords: | |
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