Viral influences on aflatoxin formation by Aspergillus flavus |
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| Authors: | Frank Rainer Schmidt Paul A Lemke Karl Esser |
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| Institution: | (1) Lehrstuhl für Allgemeine Botanik, Ruhr-Universität, Postfach 102148, D-4630 Bochum, Federal Republic of Germany;(2) Dept. of Botany and Microbiology, Auburn University, 36849 Auburn, AI, USA;(3) Present address: Abt. NeuProdukte, Hoechst AG, Postfach 80 03 20, D-6230 Frankfurt 80, Federal Republic of Germany |
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| Abstract: | Summary A nontoxigenic isolate of Aspergillus flavus (NRRL 5565) contains a viral genome consisting of 3 double-stranded RNA (ds-RNA) components with molecular weights of approximately 3 kb each. It thus shares a characteristical feature with a virus occuring in strains of Penicillium chrysogenum.Application of known inhibitors of doublestranded RNA virus synthesis results in stable aflatoxin formation by this originally nontoxigenic strain and the simultaneous loss of its ds-RNA traits. Since the inhibitor induced toxicity can be completely reverted by incubation with a virus from Penicillium chrysogenum (PcV), it is presumed that PcV or a functional related virus possibly constitutes the aflatoxin repressing determinant in Aspergillus flavus. |
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