Fine structure of neurons synthesizing vasoactive intestinal peptide in the human colon from patients with Hirschsprung's disease |
| |
| Authors: | T. Tsuto H. L. Obata-Tsuto N. Iwai T. Takahashi Y. Ibata |
| |
| Affiliation: | (1) Division of Surgery, Children's Research Hospital, Kawaramachi-Hirokoji, Kamigyo-ku, 602 Kyoto, Japan;(2) First Department of Surgery, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602 Kyoto, Japan;(3) Department of Anatomy, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602 Kyoto, Japan |
| |
| Abstract: | Summary The fine structure of neuronal perikarya and processes containing VIP-like immunoreactive material in the colon of patients with Hirschsprung's disease was investigated by immunoelectron microscopy. No VIP-like immunoreactive terminals were found in Auerbach's plexus of the ganglionic segment. However, VIP-like immunoreactive preterminal axons were frequently found to make synaptic contact with both immunoreactive and non-immunoreactive elements within Meissner's plexus. Therefore, the function of the VIP neurons in Auerbach's plexus seems to differ from that in Meissner's plexus. In the oligoganglionic segment, there were a few VIP-like immunoreactive processes, but no VIP-like immunoreactive synaptic formations. VIP-like immunoreactive processes were rarely encountered in the aganglionic segment. In both the oligo-and aganglionic segments, bowel relaxation is considered to be disturbed due to the lack of synaptic contacts of VIP-like immunoreactive neurons with other neuronal components.This work was supported in part by a grant (no. 57370002) from the Ministry of Education, Science and Culture, Japan |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
