No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA |
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| Authors: | Sigal Nadejda Molshanski-Mor Shahar Bibi Eitan |
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| Institution: | Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel. |
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| Abstract: | The largest family of solute transporters (major facilitator superfamily MFS]) includes proton-motive-force-driven secondary transporters. Several characterized MFS transporters utilize essential acidic residues that play a critical role in the energy-coupling mechanism during transport. Surprisingly, we show here that no single acidic residue plays an irreplaceable role in the Escherichia coli secondary multidrug transporter MdfA. |
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