Bluetongue virus VP4 is an RNA-capping assembly line |
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| Authors: | Sutton Geoff Grimes Jonathan M Stuart David I Roy Polly |
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| Institution: | Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK. |
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| Abstract: | Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure. |
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