New classification of <Emphasis Type="Italic">HLA-DRB1</Emphasis>alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples |
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Authors: | Thomas Barnetche Arnaud Constantin Alain Cantagrel Anne Cambon-Thomsen Pierre-Antoine Gourraud |
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Institution: | Department of Epidemiology and Public Health, UMR Inserm U 558, University Paul Sabatier Toulouse III, Faculty of Medicine Purpan, 37 Allées Jules Guesde, Toulouse cedex 7, 31073, France. barnetch@cict.fr |
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Abstract: | Introduction Rheumatoid arthritis (RA) is a complex polygenic disease of unknown etiology. HLA-DRB1 alleles encoding the shared epitope (SE) (RAA amino acid pattern in positions 72 to 74 of the third hypervariable region
of the DRβ1 chain) are associated with RA susceptibility. A new classification of HLA-DRB1 SE alleles has been developed by Tezenas du Montcel and colleagues to refine the association between HLA-DRB1 and RA. In the present study, we used RA samples collected worldwide to investigate the relevance of this new HLA-DRB1 classification in terms of RA susceptibility across various Caucasoid and non-Caucasoid patients. |
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