The coupling of epigenome replication with DNA replication |
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| Authors: | Liu Qian Gong Zhizhong |
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| Affiliation: | 1 State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China;2 China Agricultural University-University of California-Riverside Center for Biological Sciences and Biotechnology, Beijing, 100193, China;3 National Center for Plant Gene Research, Beijing, 100193, China |
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| Abstract: | In multicellular organisms, each cell contains the same DNA sequence, but with different epigenetic information that determines the cell specificity. Semi-conservative DNA replication faithfully copies the parental nucleotide sequence into two DNA daughter strands during each cell cycle. At the same time, epigenetic marks such as DNA methylation and histone modifications are either precisely transmitted to the daughter cells or dynamically changed during S-phase. Recent studies indicate that in each cell cycle, many DNA replication related proteins are involved in not only genomic but also epigenomic replication. Histone modification proteins, chromatin remodeling proteins, histone variants, and RNAs participate in the epigenomic replication during S-phase. As a consequence, epigenome replication is closely linked with DNA replication during S-phase. |
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