Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist |
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| Authors: | Weigand Stefan Bischoff Hilmar Dittrich-Wengenroth Elke Heckroth Heike Lang Dieter Vaupel Andrea Woltering Michael |
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| Institution: | BAYER Health Care AG, Pharma Research, D-42096 Wuppertal, Germany. stefan.weigand@roche.com |
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| Abstract: | We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor delta (PPARdelta) based on a lead structure from our PPARalpha program. Compound 33 showed good pharmacokinetics. |
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