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Neuroprotective effect of methanol extract of Phellodendri Cortex against 1-methyl-4-phenylpyridinium (MPP)-induced apoptosis in PC-12 cells |
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| Authors: | Hyo Won Jung Sung Yun Kim Yong-Ki Park |
| Institution: | a Department of Herbology, College of Oriental Medicine, Dongguk University, Gyeongju 780-714. Republic of Korea b Oriental Medicine Research Institute, Dongguk University, Gyeongju 780-714, Republic of Korea c Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-747, Republic of Korea |
| Abstract: | Phellodendri Cortex (PC) is a traditional herbal medicine, widely used in Korea and China. The effects of the methanol extract of Phellodendri Cortex (PC extract) on 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal apoptosis in PC-12 cells have been investigated. MPP+-induced apoptosis in PC-12 cells was accompanied by an increased bax/bcl-2 ratio, release of cytochrome c to the cytosol and activation of caspase-3. PC extract inhibited the downregulation of bcl-2 and the upregulation of bax, as well as the release of mitochondrial cytochrome c into the cytosol. In addition, PC extract attenuated caspase-3 activation and cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that the PC extract has protective effects against MPP+-induced neuronal apoptosis in PC-12 cells. |
| Keywords: | Apoptosis Neuroprotection PC-12 cells Phellodendri Cortex 1-Methyl-4-phenylpyridinium |
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