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Variability of a diterpene with potential anti-HIV activity isolated from the Brazilian brown alga <Emphasis Type="Italic">Dictyota menstrualis</Emphasis> |
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| Authors: | Diana?Negr?o?Cavalcanti Meire-Anne?Rezende?de?Oliveira Joel?Campos?De-Paula Leandro?Silva?Barbosa Tamara?Fogel Marcelo?Alves?Pinto Izabel?Christina?Nunes?de?Palmer Paix?o |
| Institution: | 1.Programa de Pós-Gradua??o em Biologia Marinha, Departamento de Biologia Marinha, Instituto de Biologia,Universidade Federal Fluminense,Niterói,Brazil;2.Instituto de Biociências, Universidade Federal do Estado do Rio de Janeiro,Rio de Janeiro,Brazil;3.Funda??o Oswaldo Cruz,Rio de Janeiro,Brazil;4.Departamento de Biologia Celular e Molecular, Instituto de Biologia,Universidade Federal Fluminense,Niterói,Brazil |
| Abstract: | This study evaluated the variability in the production of an HIV-1 antiviral diterpene in individuals of Dictyota menstrualis throughout reproductive stages. The brown alga Dictyota has an isomorphic biphasic life cycle. The quantification of the active principle by GC–FID indicated a greater production of the diterpene in the female gametophytic phase (42.11 ppm). However, these individuals had the highest variation between individuals (standard deviation of 68.20 ppm in the range from 0.39 to 227 ppm). Sporophytic individuals showed less variability. This variability in the production of the antiviral diterpene is important to the development of future antiviral drugs. |
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