Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers |
| |
| Authors: | Saedis Saevarsdottir Bo Ding Kristjan Steinsson Gerdur Grondal Helgi Valdimarsson Lars Alfredsson Lars Klareskog Leonid Padyukov |
| |
| Institution: | 1.Rheumatology Unit, Department of Medicine,Karolinska University Hospital Solna,Stockholm,Sweden;2.Institute of Environmental Medicine, Karolinska Institutet,Stockholm,Sweden;3.Department of Immunology,Landspitali University Hospital,Reykjavik,Iceland;4.Center for Rheumatology Research,Landspitali University Hospital,Reykjavik,Iceland |
| |
| Abstract: | Introduction Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA).
We re-evaluated this in context of the main environmental and genetic risk factors (smoking, HLA-DRB1 'shared epitope' (SE),
PTPN22*620W), which predispose to rheumatoid factor (RF) and/or anti-citrullinated-protein antibody (ACPA)-positive RA. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
