Muscle Potassium and Potassium Losses During Hypokinesia in Healthy Subjects |
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Authors: | Yuri F Federenko Viktor A Deogenov Kostas K Kakuris Kostas B Yerullis |
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Institution: | (1) Institute of Hypokinetic Biochemistry, Athens, Greece;(2) European Foundation of Environmental Sciences, Odos Agias Sophias 81, 162 32 Athens, Greece; |
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Abstract: | Hypokinesia (HK) induces electrolyte losses in electrolyte-deficient tissue, yet the mechanisms of electrolyte losses in electrolyte-deficient
tissue remain unknown. Mechanisms of electrolyte deposition could be involved. To determine the effect of prolonged HK on
potassium (K+) deposition were measured muscle K+ content and K+ losses. Studies were conducted on 20 physically healthy male volunteers during 30 days pre-experimental period and 364 days
experimental period. Subjects were equally divided into two groups: control subjects (CS) and experimental subjects (ES).
The CS group was run average distances of 9.8 ± 1.7 km day−1 and the ES group was walked average distances of 2.7 ± 0.6 km day−1. Muscle K+ content decreased (p < 0.05) and plasma K+ concentration, and K+ losses in urine and feces increased (p < 0.05) in the ES group compared to their pre-experimental level and the values in their respective CS group. Muscle K+ content, plasma K+ level, and urine and fecal K+ losses did not show any changes in the CS group compared to their pre-experimental values. The conclusion was that K+ losses in K+-deficient muscle of healthy subjects could have been attributable to the less efficient K+ deposition inherently to prolonged HK. |
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