Chiral synthesis of alpha-phenylpyridylmethanols with Rhizopus arrhizus |
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| Authors: | Neeta A Salvi Sanninje R Udupa Asoke Banerji |
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| Institution: | (1) Bio-Organic Division, Bhabha Atomic Research Centre, Microbial Chemistry Section, Mumbai, India |
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| Abstract: | The bioreduction of 2-benzoylpyridine (1a) with Rhizopus arrhizus afforded (S)-(+)-alpha-phenyl-2-pyridylmethanol (2a) in 82% enantiomeric excess (e.e.) while the asymmetric hydrolysis of its racemic acetate resulted in the antipode (R)-(-)-2a with 24% optical purity. |
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