Morphological aspects of human lymphoid cells grown in vitro

Summary An established immunoglobulin-producing human cell line exhibits a variety of morphological entities described as reticular, lymphoid, and plasmacytoid cells. Transitional forms are frequent, and time lapse photomicrography experiments demonstrate morphological interconversion. The round forms and their morphological precursors synthesize immunoglobulin and constitute about 44% of the cell population. This cell line displays a variety of morphological and functional properties assigned to in vivo lymphoid cell series. It is proposed as an in vitro model for the study of lymphoid cells Supported by Grant CA06939-05 and by Special Research Career Development Fellowship Award 1F03 CA42078 from the United States Public Health Service.