Transmembrane Ca2+ gradient and function of membrane proteins |
| |
Authors: | F. Y. Yang Y. G. Huang Y. P. Tu |
| |
Affiliation: | (1) National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, 100101 Beijing, China |
| |
Abstract: | This review will focus on the recent advance in the study of effect of transmembrane Ca2+ gradient on the function of membrane proteins. It consits of two parts: 1. Transmembrane Ca2+ gradient and sarcoplasmic reticulum Ca2+-ATPase; 2. Effect of transmembrane Ca2+ gradient on the components and coupling of cAMP signal transduction pathway. The results obtained indicate that a proper transmembrane Ca2+ gradient may play an important role in modulating the conformation and activity of SR Ca2+-ATPase and the function of membrane proteins involved in the cAMP signal transduction by mediating the physical state change of the membrane phospholipids.Abbreviations Cai Ca2+ inside vesicles - Ca0 Ca2+ outside vesicles - SR sarcoplasmic reticulum - PC phosphatidylcholine - PS phosphatidylserine - PG phosphatidylglycerol - PE phosphatidylethanolamine - DPH 1,6-diphenyl-1,3,5-hexatriene - n-AS n-(9-anthroyloxy) fatty acids - TMA-DPH 1-(4-trimethylammoniumphenyl)-6)-phenyl-1,3,5-hexatriene - FCCP carbonylcyanide-p-trifluoromethoxyphenylhydrazone - -AR -adrenergic receptors - DHA dihydroalprenolol - AC adenylate cyclase - AC·Lca+– higher Ca2+ inside vesicles - AC·Lca– – lower Ca2+ on both side of vesicles - AC·Lca++ higher Ca2+ on both side of vesicles - AC·Lca– + higher Ca2+ outside vesicles - cAMP cyclic adenosine monophosphate - Gs stimulatory GTP-binding protein - GTP guanosine triposphate - GTPS guanosine 50-(3-thiotriphosphate) |
| |
Keywords: | Ca2+-ATPase cAMP signal transduction transmembrane Ca2+ gradient lipid fluidity |
本文献已被 SpringerLink 等数据库收录! |
|