Transmembrane Ca2+ gradient and function of membrane proteins |
| |
Authors: | F Y Yang Y G Huang Y P Tu |
| |
Institution: | (1) National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, 100101 Beijing, China |
| |
Abstract: | This review will focus on the recent advance in the study of effect of transmembrane Ca2+ gradient on the function of membrane proteins. It consits of two parts: 1. Transmembrane Ca2+ gradient and sarcoplasmic reticulum Ca2+-ATPase; 2. Effect of transmembrane Ca2+ gradient on the components and coupling of cAMP signal transduction pathway. The results obtained indicate that a proper transmembrane Ca2+ gradient may play an important role in modulating the conformation and activity of SR Ca2+-ATPase and the function of membrane proteins involved in the cAMP signal transduction by mediating the physical state change of the membrane phospholipids.Abbreviations Cai
Ca2+ inside vesicles
- Ca0
Ca2+ outside vesicles
- SR
sarcoplasmic reticulum
- PC
phosphatidylcholine
- PS
phosphatidylserine
- PG
phosphatidylglycerol
- PE
phosphatidylethanolamine
- DPH
1,6-diphenyl-1,3,5-hexatriene
- n-AS
n-(9-anthroyloxy) fatty acids
- TMA-DPH
1-(4-trimethylammoniumphenyl)-6)-phenyl-1,3,5-hexatriene
- FCCP
carbonylcyanide-p-trifluoromethoxyphenylhydrazone
- -AR
-adrenergic receptors
- DHA
dihydroalprenolol
- AC
adenylate cyclase
- AC·Lca+–
higher Ca2+ inside vesicles
- AC·Lca– –
lower Ca2+ on both side of vesicles
- AC·Lca++
higher Ca2+ on both side of vesicles
- AC·Lca– +
higher Ca2+ outside vesicles
- cAMP
cyclic adenosine monophosphate
- Gs
stimulatory GTP-binding protein
- GTP
guanosine triposphate
- GTP S
guanosine 5 0-(3-thiotriphosphate) |
| |
Keywords: | Ca2+-ATPase cAMP signal transduction transmembrane Ca2+ gradient lipid fluidity |
本文献已被 SpringerLink 等数据库收录! |
|