| 非编码RNA和RNA沉默 |
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| 引用本文： | 毛新国,董玉琛.非编码RNA和RNA沉默[J].生物技术通报,2004(1):6-12,22. |
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| 作者姓名： | 毛新国 董玉琛 |
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| 作者单位： | 中国农业科学院作物品种资源研究所农业部作物种质资源与生物技术重点开放实验室,北京,100081 |
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| 摘 要： | 生物体内存在大量的非编码RNA ,它们形态各异 ,功能也千差万别 ,在生物的生长、发育、分化进程中扮演着不同的角色 ,尤其是siRNA ,它是RNA沉默的诱因。RNA沉默是真核生物特有的现象 ,它需要一系列因子的参与 ,其中RNA依赖性的RNA聚合酶是沉默起始的关键 ,Dicer酶是形成siRNA的基础 ,而RNA沉默诱导复合体 (RSIC)等是发生RNA沉默“链式反应”的关键因子
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| 关 键 词： | 非编码RNA RNA沉默 小干扰RNA RNA依赖性RNA聚合酶(RdRP) Dicer酶 RNA诱导沉默复合体(RISC) |
Noncoding RNA and RNA Silencing |
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| Mao Xinguo,Dong Yuchen.Noncoding RNA and RNA Silencing[J].Biotechnology Bulletin,2004(1):6-12,22. |
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| Authors: | Mao Xinguo Dong Yuchen |
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| Abstract: | Many non translatable non coding RNA have been found in different organisms. They play a variety of structural, informational, catalytic and regulatory roles in different period of orgnism's growth, differential and development. siRNA ,the focus of recent research, is the trigger of RNA silencing. Some enzymes complexities, such as RdRP, Dicer and RISC, play critical role in different periods of the silencing chain reaction. |
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| Keywords: | Non coding RNA RNA silencing Small interfering RNA RNA dependent RNA polymerase(RdRP)Dicer enzyme RNA silencing induced complex (RISC) |
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