|
|||||
|
|
Synthesis of 2'-O-deuteriomethyl ribonucleosides Gm-d3, Am-d3, Um-d3 and Cm-d3. |
|
| Authors: | T Hashizume |
| Institution: | Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA. |
| Abstract: | The synthesis of 2'-O-deuteriomethyl ribonucleosides by iodomethane-d3 (99.5 + atom % D) deuteriomethylation of 3',5'-O-tetra(isopropyldisiloxane)-diyl nucleosides, followed by deprotection, is described. |
| Keywords: | |