A theoretical model for estimating the margination constant of leukocytes |
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Authors: | Kátia Iadocicco Luiz Henrique Alves Monteiro José Guilherme Chaui-Berlinck |
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Affiliation: | 1. Departamento de Fisiologia, Instituto de Biociências, Universidade de S?o Paulo 05508-900, S?o Paulo, SP, Brazil 2. Pós-Gradua??o, Engenharia Elétrica, Universidade Presbiteriana Mackenzie, S?o Paulo, SP, Brazil
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Abstract: | Background Blood leukocytes constitute two interchangeable sub-populations, the marginated and circulating pools. These two sub-compartments are found in normal conditions and are potentially affected by non-normal situations, either pathological or physiological. The dynamics between the compartments is governed by rate constants of margination (M) and return to circulation (R). Therefore, estimates of M and R may prove of great importance to a deeper understanding of many conditions. However, there has been a lack of formalism in order to approach such estimates. The few attempts to furnish an estimation of M and R neither rely on clearly stated models that precisely say which rate constant is under estimation nor recognize which factors may influence the estimation. |
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