Side-chain hydroxylation of vitamin D3 and its physiological implications |
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| Authors: | G Jones D Vriezen D Lohnes V Palda N S Edwards |
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| Affiliation: | Department of Biochemistry, Queen's University, Kingston, Ontario, Canada. |
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| Abstract: | Evidence is accumulating that, in vivo and in vitro, both 25-OH-D3 and 1,25-(OH)2D3 undergo side-chain modification leading to side-chain cleaved metabolites lacking the 24, 25, 26, and 27 carbons. The enzymes involved are D-dependent and are located in the kidney, bone, intestine, and perhaps other sites. We speculate that the extra-renal side-chain pathway may be primarily for target organ destruction of 1,25-(OH)2D3, whereas the renal pathway may be primarily for destruction of 25-OH-D3 formed in large amounts in hypervitaminosis D. |
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