| 向日葵胰蛋白酶抑制剂SFTI-1 |
| |
| 引用本文： | 张威,陈婷,张友尚. 向日葵胰蛋白酶抑制剂SFTI-1[J]. 生命的化学, 2010, 0(2) |
| |
| 作者姓名： | 张威 陈婷 张友尚 |
| |
| 作者单位： | 东华大学化学化工与生物工程学院;生物科学与技术研究所;中国科学院上海生命科学研究院生物化学与细胞生物学研究所; |
| |
| 摘 要： | 向日葵胰蛋白酶抑制剂(sunflower trypsininhibitor-1,SFTI-1)是近来发现的Bowman-Birk抑制剂(Bowman-Birk inhibitor,BBI)家族的新成员。由14个氨基酸残基组成的SFTI-1是具有胰蛋白酶抑制活性的天然环肽。SFTI-1的天然环状结构使它成为药物研发中的重要前导化合物。本文综述了近年来SFTI-1在结构、功能、环化机制等方面的研究进展。
|
| 关 键 词： | 向日葵胰蛋白酶抑制剂 结构 环化机制 |
Advances in the research of sunflower trypsin inhibitor-1 |
| |
| Wei Zhang,Ting Chen,You-Shang Zhang College of Chemistry,Chemical Engineering , Biotechnology,Donghua University,Shanghai ,China. Advances in the research of sunflower trypsin inhibitor-1[J]. Chemistry of Life, 2010, 0(2) |
| |
| Authors: | Wei Zhang Ting Chen You-Shang Zhang College of Chemistry Chemical Engineering & Biotechnology Donghua University Shanghai China |
| |
| Affiliation: | Wei Zhang1,Ting Chen1,You-Shang Zhang2 1College of Chemistry,Chemical Engineering & Biotechnology,Donghua University,Shanghai 201620,China,2Institute of Biochemistry , Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031 |
| |
| Abstract: | The sunflower trypsin inhibitor-1 (SFTI-1) is a recently discovered cyclic peptide with 14 amino acid residues.It is a new member of Bowman-Birk inhibitor family.Because of its high inhibitory activity on trypsin and its cyclic structure,it has been used as a new important lead compound in drug design.Here,we summarize the research of the structure,function,cyclization mechanism and application of SFTI-1. |
| |
| Keywords: | sunflower trypsin inhibitor-1 (SFTI-1) structure cyclization mechanism |
| 本文献已被 CNKI 等数据库收录！ |
|
