The emerging role of miR‐19 in glioma |
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| Authors: | Weihan Wang Anling Zhang Yubing Hao Guangxiu Wang Zhifan Jia |
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| Affiliation: | Department of Neurosurgery, Tianjin Medical University, General Hospital, Tianjin Neurological Institute, Laboratory of Neuro‐Oncology, Key Laboratory of Post‐Trauma Neuro‐Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China |
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| Abstract: | Glioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of miRNAs in glioma are toward further understanding of the pathogenesis of glioma. MiR‐19, a member of miR‐17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR‐19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR‐19, and correlation of miR‐19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR‐19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma. |
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| Keywords: | chemotherapy glioma miR‐19 radiotherapy target gene |
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