Cell Reactions Following Acute Brain Injury: A Review |
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Authors: | Norton William T |
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Institution: | (1) Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave., New York, NY, 10461 |
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Abstract: | The proliferative behavior of glia following a cerebral stab wound in adult rats is reviewed. Proliferation was determined by both PCNA and 3H]thymidine labeling. Microglia were the first cells to divide and constituted the bulk of dividing cells. Both ramified and ameboid microglia divided. A smaller number of astrocytes entered the cell cycle a day later and were shown to derive from differentiated reactive cells. No differentiated oligodendroglia were labeled by thymidine, although a small number of dividing immature oligodendroglia could be detected in cultures of cells labeled in vivo. Recent studies of the properties of oligodendroglial precursors in brain repair mechanisms are discussed. The results so far support our conclusion that differentiated oligodendrocytes do not divide. |
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Keywords: | Brain injury glia thymidine labeling |
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