Nonequilibrium Statistical Model of Active Transport of Ions and ATP Production in Mitochondria |
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Authors: | Alexey V Melkikh Vladimir D Seleznev |
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Institution: | (1) Ural State Technical University, Yekaterinburg, Russia |
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Abstract: | A model of the active transport of ions through internal membranes of mitochondria is proposed. If concentrations of ions
in a cell are known, this model allows calculating concentrations of all main ions (H+, Ca+2, K+, Mg2+, Na+, Cl−) in the mitochondrion matrix and the resting potential across the membrane. The theoretical values satisfactorily agree with
available experimental data on the concentrations and the potentials, including different operating regimes of the adenosine
triphosphate (ATP) synthetase (the main regime, short circuiting or ATP synthetase blocking). The active transport of Mg2+ ions in exchange for protons was assumed. In accordance with the model, the ATP synthetase operation is possible only if
the stoichiometric coefficient of protons is 3. |
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Keywords: | Active transport of ions Mitochondria ATP production Resting potential Mathematical model |
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